It's all in the Name
The domain you use for a particular site can have a huge impact in the way that humans and search engine spiders perceive it. Domain names were once so expensive that only those wanting to protect a brand or who could afford them owned them, now they are commonplace and if you know where to look, you can pick up a domain name for free.
Now that they are much easier to obtain, it is hard to take any site that does not have it's own domain name very seriously. Without a domain name, a company is likely to be passed off as amateurish or seen to want to cut corners to save money. If you have a company site and you still haven't got a domain name for your website, then you might want to think about getting one!
Make it Memorable
The best domain names are those that people can remember, because if your visitors can remember it, they are more likely to come back. If you do not already have a company or other name selected for your site, then it is often a good idea to make your domain name the brand for the site. Tying your site name to the domain is just one way you can help your visitors remember how to find you again.
Tips for choosing the most memorable domain name.
keep it short and easy to spell.
make use of keywords or popular search terms whenever possible.
generic terms are like gold dust if you can get them.
the more unusual but familiar sounding a domain, the better.
add a twist, some domain names are remembered for being different to what you would expect to find there (e.g. monster.co.uk)
One of the major problems of trying to promote a specific domain name is that in general, people (or sometimes browsers) assume that they end in a .com. If your site uses a domain other than a .com, then you may want to make the domain your site identity, otherwise you could have your visitors remembering the domain name but not the extension and going to related site that isn't your own!
If you purchase your domain with the intention that it will become the brand that you promote, then it is worth taking into account the specifics of the domain. Keywords can play an important part in your brand, particularly if it is specific to your industry, as they will help to make your domain name memorable while improving your search engine rankings.
In the case of directories such as Yahoo and DMOZ sites are usually listed in alphabetical order, so anything starting with A, B or C has a much better chance of being higher on the list than those starting with X, Y or Z, and so is more likely to be noticed. Don't however be tempted to use a domain that has been "padded out" to get a high position in an alphabetically sorted list; not only will it look tacky and amateurish, but most directories use human editors who would pick up this obvious trick and either correct it or ignore the site altogether.
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